Introduction to Sequence Alignment
- Sequence comparison
- Protein sequences: amino acids and their properties
- Why do we need to compare sequences?
- Find dissimilarities
- Similar sequences = similar properties
- Similar sequences = common ancestral genes
- Mutations -> Gapless alignments
- Mutations, insertions and deletions -> Gapped alignment
- Sequence alignments
- Score = edit distance
- Examples of scores
- Length of alignment, number of alignments
- Algorithms for sequence alignments
- Dynamics programming
- Example
- Global and Local alignments
-
BLAST
- How it works
- Examples