Foundations of Molecular Evolution and Population Genetics
- Review of the central dogma
- Replication
- Coding sequence
- Genetic code
- Mutations, DNA variation
- Synonymous
- Non-synonymous
- Foundations of genetics
- One locus
- Genotype
- Haploids vs diploids
- Homo/heterozygosis, allele frequency
- Dominant vs recessive (PDF): blood types
- Random mating: Hardy-Weinberg equilibrium
- One locus
- Genetic Drift
- Dynamics in population of constants size
- N=1
- Reduction of heterozygosity
- N>>1, Binomial sampling
- Probability of fixation: simulation 1, simulation 2
- Time to fixation
- Selection
- Absolute and relative fitness
- Writes equations: increase of fitness
- Selection and Drift
- Probability of fixation: (diploids, s, N, h=1/2)
- Time to fixation
- Summary