Required Textbooks
Weiss, Thomas F. Cellular Biophysics: Transport. Vol. 1. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231831.
———. Cellular Biophysics: Electrical Properties. Vol. 2. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231848.
| ses # | Topics | READINGS |
|---|---|---|
| L1 | Introduction to Cellular Transport | |
| R1 | Review of Differential Equations | |
| L2 | Macroscopic and Microscopic Laws of Diffusion | Weiss. Volume 1: 3.1-3.1.3, 3.2-3.2.2. |
| L3 | Continuity and Diffusion Equations | Weiss. Volume 1: 3.1.4-3.1.5, 3.5-3.5.2.1. |
| R2 | Diffusion | |
| L4 | Diffusion in Cells: Models | Weiss. Volume 1: 3.6-3.6.1.2, 3.7-3.7.2. |
| R3 | Diffusion (cont.) | |
| L5 | Diffusion in Cells: Experiments | Weiss. Volume 1: 3.8-3.8.5. |
| L6 | Osmosis: van Hoff's Law | Weiss. Volume 1: 4.1-4.3.2.3, 4.4-4.5.1.2. |
| R4 | Diffusion and Osmosis | |
| L7 | Osmosis in Cells: Equilibrium | Weiss. Volume 1: 4.7-4.7.1.2. |
| R5 | Osmosis | |
| L8 | Chemical Transport | Weiss. Volume 1: 4.7.2-Fig. 4.26 (p. 230), Fig. 4.28, 4.8.2-4.8.3, 6.1-6.2.1.4. |
| L9 | Four-State Symmetric Carrier Model | Weiss. Volume 1: 6.4-6.4.1.4. |
| R6 | Osmosis and Carrier Mediated Transport | |
| L10 | Carrier Models | Weiss. Volume 1: 6.4.2-6.4.3, 6.6-6.7.4. |
| R7 | 4-State Model | |
| L11 | Glucose Regulation | Weiss. Volume 1: 7.2.1, 7.2.3, 7.2.4.1, 7.4. |
| L12 | Ion Transport: Nernst-Planck Equation | |
| R8 | Carrier Models | |
| L13 | Writing a Laboratory Report | |
| Exam 1 | ||
| L14 | Ion Transport: Models | |
| R9 | Ions | |
| L15 | Ion Transport Models (cont.) | Weiss. Volume 1: 7.5. |
| R10 | Ions (cont.) | |
| L16 | Active Transport | Weiss. Volume 1: 7.5. |
| L17 | Electrical Properties of Cells | Weiss. Volume 2: Chapter 1. |
| Writing Clinic | ||
| L18 | Core Conductor Model of Large Cells | Weiss. Volume 2: 2.1-2.4.2. |
| R11 | Core Conductor | |
| L19 | Core Conductor | Weiss. Volume 2: 2.4.3-2.5. |
| L20 | HH: Space Clamp | Weiss. Volume 2: 4.1-4.1.2.3, 4.2-4.2.2.2. |
| R12 | Core Conductor (cont.) | |
| L21 | HH: Voltage Clamp | Weiss. Volume 2: 4.2.3-4.2.3.1. |
| R13 | Core Conductor (cont.) | |
| L22 | HH: Current Clamp | Weiss. Volume 2: 4.2.3-4.2.3.2. |
| L23 | Demo: HH Project | Weiss. Volume 2: 4.3. |
| R14 | HH Elec Classroom | |
| L24 | HH Project | Weiss. Volume 2: 4.4.8. |
| Exam 2 | ||
| L25 | HH: Threshold | Weiss. Volume 2: 4.4.1. |
| L26 | Cable Model | Weiss. Volume 2: 3.1-3.2.1, 3.3-3.4.2.1. |
| R15 | HH Elec Classroom (cont.) | |
| L27 | Cable Model (cont.) | |
| L28 | Writing an Oral Presentation | Weiss. Volume 2: 3.4.2.4-3.4.3.1, 3.4.3.3-3.5. |
| L29 | Myelinated Fibers | Weiss. Volume 2: 5.1-5.2.4.4. |
| R16 | Cable Model | |
| L30 | Saltatory Conduction | Weiss. Volume 2: 5.3-5.7. |
| R17 | Saltatory Conduction | |
| L31 | Patch Clamp | Weiss. Volume 2: 6.1-6.1.1, 6.4-6.4.1.5, 6.2-6.2.2, 6.5-p. 407. |
| L32 | Ion Channels: 2-State Models | Weiss. Volume 2: 6.5-p. 407. |
| HH Dry Runs | ||
| L33 | Ion Channels: 4 Gate Model | Weiss. Volume 2: p. 407-p. 416. |
| L34 | Ion Channels: Gating Currents | Weiss. Volume 2: 6.3.2-6.3.6. |
| R18 | Ion Channels | |
| R19 | Ion Channels (cont.) | |
| L35 | Ion Channels Multi-State Models | Weiss. Volume 2: 6.6, 6.7. |
| R20 | Ion Channels (cont.) | |
| L36 | Breakfast with the Staff | |
| R21 | Ion Channels (cont.) | |
| Final Exam Period |