These lecture notes were prepared by Tiffany Iaconis, Frederick Jao, and Vicky Loewer for MIT OpenCourseWare. They are preliminary and may contain errors.
Instructors:
WHG = William H. Green
KDW = K. Dane Wittrup
| LEC # | TOPICS |
|---|---|
| 1 | Preliminaries and remembrance of things past. Reaction stoichiometry, lumped stoichiometries in complex systems such as bioconversions and cell growth (yields); extent of reaction, independence of reactions, measures of concentration. Single reactions and reaction networks, bioreaction pathways. (WHG) (PDF) |
| 2 | The reaction rate and reaction mechanisms: Definition in terms of reacting compounds and reaction extent; rate laws, Arrhenius equation, elementary, reversible, non-elementary, catalytic reactions. (WHG) (PDF) |
| 3 | Kinetics of cell growth and enzymes. Cell growth kinetics; substrate uptake and product formation in microbial growth; enzyme kinetics, Michaelis-Menten rate form. (KDW) (PDF) |
| 4 | Reaction mechanisms and rate laws: Reactive intermediates and steady state approximation in reaction mechanisms. Rate-limiting step. Chain reactions. Pyrolysis reactions. (WHG) (PDF) |
| 5 | Continuous stirred tank reactor (CSTR). Reactions in a perfectly stirred tank. Steady-state CSTR. (KDW) (PDF) |
| 6 |
Concentration that optimizes desired rate. Selectivity vs. Conversion. Combining reactors with separations. (WHG) (PDF) Lecture 6 correction (PDF) |
| 7 | Batch reactor: Equations, reactor sizing for constant volume and variable volume processes. (KDW) (PDF) |
| 8 | The plug flow reactor. (WHG) (PDF) |
| 9 | Reactor size comparisons for PFR and CSTR. Reactors in series and in parallel. How choice of reactor affects selectivity vs. conversion. (KDW) (PDF) |
| 10 | Non-ideal reactor mixing patterns. Residence time distribution. Tanks in series model. Combinations of ideal reactors. (KDW) (PDF) |
| 11 | Non isothermal reactors. Equilibrium limitations, stability. Derivation of energy balances for ideal reactors; equilibrium conversion, adiabatic and nonadiabatic reactor operation. (WHG) (PDF) |
| 12 | Data collection and analysis. Experimental methods for the determination of kinetic parameters of chemical and enzymatic reactions; determination of cell growth parameters; statistical analysis and model discrimination. (WHG) (PDF) |
| 13 | Biological reactors - chemostats. Theory of the chemostat. Fed batch or semi-continuous fermentor operation. (KDW) (PDF) |
| 14 | Kinetics of non-covalent bimolecular interactions. Significance; typical values and diffusion limit; approach to equilibrium; multivalency. (KDW) (PDF) |
| 15 | Gene expression and trafficking dynamics. Approach to steady state; receptor trafficking. (KDW) (PDF) |
| 16 | Catalysis. Inorganic and enzyme catalysts and their properties; kinetics of heterogeneous catalytic reactions; adsorption isotherms, derivation of rate laws; Langmuir-Hinshelwood kinetics. (WHG) (PDF) |
| 17 | Mass transfer resistances. External diffusion effects. Non-porous packed beds and monoliths, immobilized cells. (WHG) (PDF) |
| 18 | External mass-transfer resistance: Gas-liquid reactions in multiphase systems. (KDW) (PDF) |
| 19 | Oxygen transfer in fermentors. Applications of gas-liquid transport with reaction. (KDW) (PDF) |
| 20 | Reaction and diffusion in porous catalysts. Effective diffusivity, internal and overall effectiveness factor, Thiele modulus, apparent reaction rates. (KDW) (PDF) |
| 21 | Reaction and diffusion in porous catalysts (cont.). Packed bed reactors. (WHG) (PDF) |
| 22 |
Combined internal and external transport resistances. (WHG) (PDF) Biot numbers review. (PDF) (Courtesy of David Adrian. Used with permission.) |
| 23 | Pulling it all together; applications to energy/chemicals industry. Presentation of current research. (WHG) |
| 24 | Pulling it all together; applications to bioengineering and medicine. Presentation of current research. (KDW) |
| 25 | Course review. (WHG) (PDF) |