Session Key
L = Lecture
R = Recitation
E = Exam
Lecturer Key
|
PD = Prof. Peter Dedon MM = Dr. Mark Murcko ST = Prof. Steven Tannenbaum |
CK = Dr. Charles Knutson GL = Guest lecturer TA = Teaching assistants |
| SES # | TOPICS | LECTURERS | KEY DATES |
|---|---|---|---|
| Overview of the Drug Discovery Process; Fundamental Principles | |||
| L1 | Introduction and Fundamentals | PD, MM, ST | |
| L2 | Overview of Drug Development 1 | MM | |
| L3 | Overview of Drug Development 2 | MM | |
| R1 | Fundamentals | PD | |
| L4 | Biochemistry Review Exercise | CK | |
| L5 | Uptake and Distribution | PD | |
| L6 | Dr. Keith Hoffmaster, Novartis: Drug Transporters 1 | GL | |
| L7 | Dr. Keith Hoffmaster, Novartis: Drug Transporters 2 | GL | Drug Metabolism Problem Sets Due |
| R2 | Drug Metabolism 1 | ST | |
| L8 | Drug Metabolism 2 | ST | |
| L9 | Drug Toxicity 1 | ST | |
| R3 | Lecture Review Session | TA | |
| L10 | Drug Toxicity 2 | ST | |
| L11 | Pharmacokinetics | PD | |
| R4 | Quiz Review | PD, TA |
Fundamentals Problem Set Due Pharmacokinetics Problem Set Due |
| E | Exam | ||
| Case Studies and Literature Discussions; Case Study Project | |||
| L12 | Case Study: Omeprazole Pharmacogenetics | PD | |
| R5 | Overview of Drug Development 3 | MM | Case Study Project Topic Due |
| L13 | Case Study | MM | |
| L14 | Case Study: Antibiotics | CK | |
| R6 | Project Help Session | TA | |
| L15 | Case Study | ST | |
| L16 | Dr. Alex Wood, MIT Senior Lecturer / Novartis: Case Study: Oncology Drugs | GL | |
| R7 | Project Help Session | TA | |
| L17 | Case Study: Statins | PD | |
| R8 | Project Help Session | TA | |
| L18 | Case Study: GWAS and Statin Toxicity | PD | |
| L19 | Dr. Bernard Fermini, Pfizer: Case Study: Cardiotoxicity | GL | |
| R9 | Project Help Session | TA | |
| L20 | Dr. Teresa Wright, Shire Pharmaceuticals: Preclinical Drug Development | GL | |
| R10 | Project Help Session | TA | |
| L21 | Dr. Keith Hoffmaster: Case Study: PK / PD | GL | |
| L22 | Case Study: Sarilumab Phase III Clinical Result | MM | |
| R11 | Prof. Doug Lauffenburger: Systems Pharmacology | GL | |
| L23 | Dr. Tess Schmalbach, Schmalbach LLC: The Clinical Size of Drug Development | GL | Case Study Project Paper Due |