Several lectures are given by the course TA Dr. Ikuo Taniguchi.
| Lec # | TOPICS |
|---|---|
| 1 |
Course Introduction (PDF) Biomaterials Defined Structural Hierarchy in Materials and Biology |
| 2 |
Biomaterials Surfaces: Physics (PDF) Surface (vs. Bulk) Structure and Properties Surface Energy Adsorption, Segregation, and Reconstruction at Surfaces |
| 3 |
Biomaterials Surfaces: Chemistry (PDF) Reactions at Surfaces: Chemisorption, Corrosion |
| 4 |
Biomaterials Surfaces: Chemistry (cont.) (PDF) Hydrolysis (Dr. Taniguchi) (PDF - 1.3 MB) |
| 5 |
Protein-Surface Interactions ( PDF)Proteins: Structure, Properties, Functions Protein Adsorption: Langmuir Model |
| 6 |
Protein-Surface Interactions (cont.) (PDF) Protein Adbsorption: Complex Phenomena, Measurement |
| 7 |
Cell-Surface Interactions: Host Response to Biomaterials (PDF - 1.3 MB) Cell Adhesion Mechanisms Coagulation Cascade |
| 8 |
Cell-Surface Interactions: Host Response to Biomaterials (cont.) (PDF) Immune Response: Alternative Complement Activation |
| 9 |
Surface Modification Methods (PDF) Purposes Plasma Treatments Organic Coatings (Dr. Taniguchi) (PDF) |
| 10 |
Surface Modification Methods (cont.) (PDF) Polymer Coatings Patterned Surfaces |
| 11 |
Surface Characterization (PDF) In Vacuum: XPS/ESCA, AES, SIMS |
| 12 |
Surface Characterization In situ (PDF) Contact Angle, AFM |
| 13 |
Quantifying Cell Behavior (PDF) Cell Cultures Cellular Assays: Adhesion, Migration, Proliferation |
| 14 |
Quantifying Cell Behavior (cont.) (PDF) Cellular Assays: Differentiation, Function |
| 15 |
Statistical Analysis (PDF) Error Sources, Distribution Functions, t- test |
| 16 |
Statistical Analysis (cont.) (PDF) Fisher Test, Regression Methods |
| 17 |
Biosensors and Diagnostic Devices (PDF) Biological Elements Transduction Mechanisms Properties Examples: Fiber Optic Biosensors, Nanobarcodes |
| 18 |
Drug Delivery: Controlled Release (Dr. Taniguchi) (PDF) Chemically-controlled Devices |
| 19 |
Drug Delivery: Controlled Release (cont.) (PDF) Diffusion-controlled, Membrane-based and Osmotic Devices |
| 20 |
Drug Delivery: Controlled Release (cont.) (PDF) Methods: Transdermal, Colloidal Vehicles Mechanical Pumps |
| 21 |
Biomaterials for Organ Replacement (PDF) Organ Replacement Therapies Mechanical Properties Bone Substitutes |
| 22 |
Tissue Engineering (PDF) Cell Types Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation Scaffolds: Design and Fabrication |
| 23 |
Tissue Engineering (cont.) (PDF) Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration |
| 24 | FDA Regulatory Issues and Course Evaluations (PDF) |