| SES # | TOPICS | STUDY QUESTIONS | READINGS |
|---|---|---|---|
| 1 | Lecture: Introduction | Ions, Channels, Currents, and Electrical Potentials (PDF) Bibliography of Discussion Papers (PDF) Electronic Resources (PDF) |
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| 5 | Discussion: Anatomy | (PDF) | Forge, A., and T. Wright. "The molecular architecture of the inner ear." Br Med Bull 63 (2002): 5-24. Kikuchi, T., R. S. Kimura, D. L. Paul, and J. C. Adams. "Gap junctions in the rat cochlea: immunhistochemical and ultrastructural analysis." Anat Embryol 191 (1995): 101-118. Liberman, M. C. "Morphological differences among radial afferent fibers in the cat cochlea: An electron-microscopic study of serial sections." Hear Res 3 (1980): 45-63. ———. "Single-neuron labeling in the cat auditory nerve." Science 216 (1982): 1239-1241. |
| 7 | Discussion: Hair Cells and Transduction | (PDF) | Roberts, W. M., and J. Howard, et. al. "Hair cells: transduction, tuning, and transmission in the inner ear." Annu Rev Cell Biol 4 (1988): 63-92. Corey, D. P., and A. J. Hudspeth. "Kinetics of the receptor current in bullfrog saccular hair cells." J Neurosci 3 (1983): 962-976. Pickles, J. O., S. D. Comis, and M. P. Osborne. "Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction." Hear Res 15 (1984): 103-112. Denk, W., J. R. Holt, G. M. Shepherd, and D. P. Corey. "Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links." Neuron 15 (1995): 1311-1321. |
| 10 | Discussion: Stria and Endocochlear Potential | (PDF) | Wangemann, P. "K+ cycling and its regulation in the cochlea and vestibular labyrintl." Audiology Neurootology 7 (2002): 199-205. Salt, A. N., I. Melichar, and R. Thalmann. "Mechanisms of endocochlear potential generation by stria vascularis." Laryngoscope 97 (1987): 984-991. Takeuchi, S., M. Ando, and A. Kakigi. "Mechanism generating endocochlear potential: role played by intermediate cells in stria vascularis." Biophys J 79 (2000): 2572-2582. |
| 12 | Discussion: Electromotility and OHCs | (PDF) | Santos-Sacchi, J. "New tunes from Corti's organ: the outer hair cell boogie rules." Curr Opin Neurobio 13 (2003): 459-468. Holley, M. C., and J. F. Ashmore. "On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea." Proc R Soc Lond B Biol Sci 232 (1988): 413-429. Hallworth, R., B. N. Evans, and P. Dallos. "The location and mechanism of electromotility in guinea pig outer hair cells." J Neurophysiol 70 (1993): 549-558. Zheng, J., W. Shen, D. Z. He, K. B. Long, L. D. Madison, and P. Dallos. "Prestin is the motor protein of cochlear outer hair cells." Nature 405 (2000): 149-155. |
| 14 | Discussion: Tuning and Mechanics | (PDF) | Dallos, P. "The active cochlea." J Neurosci 12 (1992): 4575-4585. Wilson, J. P., and J. R. Johnstone. "Basilar membrane and middle-ear vibration in guinea pig measured by capacitive probe." J Acoust Soc Am 57 (1975): 705-723. Ruggero, M. A., and N. C. Rich. "Furosemide alters organ of Corti mechanics: Evidence for feedback of outer hair cells upon the basilar membrane." J Neurosci 11 (1991): 1057-1067. Neely, S. T. "A model of cochlear mechanics with outer hair cell motility." J Acoust Soc Amer 94, no. 1 (1993): 137-146. |
| 16 | Discussion: Afferent Transmission | (PDF) | Fuchs, P. A., E. Glowatski, and T. Moser. "The afferent synapse of cochlear hair cells." Curr Opin Neurobio 13 (2003): 452-458. Richards, Griesinger, and Ashmore. "Fast vesicle replenishment allows indefatigable signaling at the first auditory synapse." Nature 435 (2005): 212-215. Moser, T., and D. Beutner. "Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse." Proc Nat Acad Sci 97 (2000): 883-888. Glowatzki, E., and P. A. Fuchs. "Transmitter release at the hair cell ribbon synapse." Nat Neurosci 5 (2002): 147-154. |
| 19 | Discussion: Auditory Nerve Response | (PDF) |
 Kiang, N. Y. S. "Peripheral neural processing of auditory information." In Handbook of Physiology - The Nervous System III. Section 1: The Nervous System. Vol. III. Sensory Processes. Part 2. Edited by J. M. Brookhart, V. B. Mountcastle, I. Darian-Smith, and S. R. Geiger. Philadelphia, PA: Lippincott Williams and Wilkins, 1981. ISBN: 9780683011050.Liberman, M. C. "Auditory-nerve response from cats raised in a low-noise chamber." J Acoust Soc Am 63 (1978): 442-455. Sachs, M. B., and E. D. Young. "Encoding of steady-state vowels in the auditory nerve: representation in terms of discharge rate." J Acoust Soc Am 66 (1979): 470-479. Young, E. D., and M. B. Sachs. "Representation of steady state vowels in the temporal aspects of the discharge patterns of populations of auditory nerve fibers." J Acoust Soc Amer 66 (1979): 1381-1403. |
| 25 | Discussion: Efferent Control | (PDF) |
Guinan, J. J. "Physiology of olivocochlear efferents." The Cochlea. Edited by P. Dallos, A. N. Popper, and R. R. Fay. New York, NY: Springer, 1996, pp. 435-500. ISBN: 9780387944494. Elgoyhen, A. B., D. S. Johnson, J. Boulter, D. E. Vetter, and S. Heinemann. "Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells." Cell 79 (1979): 705-715. Russell, I. J., and E. Murugasu. "Medial efferent inhibition suppresses basilar membrane responses to near characteristic frequency tones of moderate to high intensities." J Acoust Soc Am 102 (1997): 1734-1738. Maison, S. F., and M. C. Liberman. "Predicting vulnerability to acoustic injury with a non-invasive assay of olivocochlear reflex strength." J Neuroscience 20 (2000): 4701-4707. |
| 28 | Discussion: Inner Ear Development | (PDF) | Barald, K., and Kelley. "From placode to polarization: new tunes in inner ear development." Development 131 (2004): 4119-4130. Torres, M., and F. Giraldez. "The development of the vertebrate ear." Mechanisms of Development 71 (1998): 5-21. Groves, A. K. and M. Bronner-Fraser. "Competence, specification and commitment in otic placode induction." Development 127 (2000): 3489-3499. Eddison, M., I. Le Roux, and J. Lewis. "Notch signaling in the development of the inner ear: lessons from Drosophila." Proc Natl Acad Sci U.S.A. 97 (2000): 11692-11699. |
| 29 | Discussion: Trauma and Repair | (PDF) | Pirvola, U., L. Xing-Qun, J. Virkkala, M. Saarma, C. Murakata, A. M. Camoratto, K. M. Walton, and J. Ylikoski. "Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation." J Neurosci 20 (2000): 43-50. Wang, Y., K. Hirose, and M. C. Liberman. "Dynamics of noise-induced cellular injury and repair in the mouse cochlea." J Assoc Res Otolaryngol 3 (2002): 248-268. Izumikawa, M., R. Minoda, K. Kawamoto, K. A. Abrashkin, D. L. Swiderski, D. F. Dolan, D. E. Brough, and Y. Raphael. "Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals." Nat Med 11, no. 3 (March 2005): 271-6. (Epub - February 13, 2005.) |
| 32 | Discussion: Sensorineural Hearing Loss | (PDF) |
Liberman, M. C. "Auditory Processing in Sensorineural Hearing Loss." Basic Science Review for Otolaryngology. Edited by T. R. Van De Water, and H. Staecker. New York, NY: Thieme Medical Publishers, 2005. ISBN: 9780865779013. Liberman, M. C., and L. W. Dodds. "Single-neuron labeling and chronic cochlear pathology, III: Stereocilia damage and alterations of threshold tuning curves." Hearing Research 16 (1984): 55-74. Heinz, M. G., and E. D. Young. "Response Growth With Sound Level in Auditory-Nerve Fibers After Noise-Induced Hearing Loss." J Neurophysiology 91 (2004): 784-795. Moore, B. C., D. A. Vickers, C. J. Plack, and A. J. Oxenham. "Inter-relationship between different psychoacoustic measures assumed to be related to the cochlear active mechanism." J Acoust Soc Amer 106, no. 5 (1999): 2761-2778. |
| 33 | Discussion: Review |
