SES # | TOPICS | KEY DATES |
---|---|---|
1 | Introduction to Class
| |
2 | Protein Conformation Review
| Assignment 1 due |
3 | β-sheet Conformations
| Assignment 2 due |
4 | Critical Features of in Vitro Refolding Reactions
| Assignment 3 due |
5 | Structure and Function of Double Barrel Chaperonins
| Assignment 4 due |
6 |
Amyloid Fibers and Neurodegenerative Disease In-Class Guest Lecturer: Prof. Peter Lansbury, Harvard Medical School, "Synuclein as a Therapeutic Target for Parkinson's Disease: Twenty Years and Counting." | Assignment 5 due |
7 | Collagen Folding and Assembly
| Assignment 6 due |
8 | Protein Deposition Diseases: Light Chain Amyloidosis, Alzheimers, Parkinson's, Huntington's, ALS and Others In-Class Guest Lecturer: Dr. Kelly Knee, Pfizer, Cambridge, "Sickle Cell Hemoglobin." | Assignment 7 due |
9 | Prions and Functional Amyloids | |
10 | Membrane Proteins
| |
11 | Chaperones
| |
12 | Student Paper Presentations
| |
13 | Student Paper Presentations
| |
14 | Student Paper Presentations
| Final Papers due |