Readings

Course readings.
WEEK #	TOPICS	READINGS
1	Introduction See the Lecture Summary	[No readings]
2	p53 first described See the Lecture Summary	Paper 1 Lane, D. P., and L. V. Crawford. "T Antigen is Bound to a Host Protein in SV40-Transformed Cells." Nature 278 (1979): 261–3. Paper 2 Linzer, D. I., and A. J. Levine. "Characterization of a 54K Dalton Cellular SV40 Tumor Antigen present in SV40-Transformed Cells and Uninfected Embryonal Carcinoma Cells." Cell 17, 43–52.
3	An oncogene turned out to be a tumor suppressor See the Lecture Summary	Paper 1 Eliyahu, D., D. Michalovitz, and M. Oren. "Overproduction of p53 Antigen Makes Established Cells Highly Tumorigenic." Nature 316 (1985): 158–60. Paper 2 Finlay, C. A., P. W. Hinds, and A. J. Levine. "The p53 Proto-Oncogene Can Act as a Suppressor of Transformation." Cell 57 (1989): 1083–93.
4	p53 mutation in cancer See the Lecture Summary	Paper 1 Srivastava, S., Z. Q. Zou, K. Pirollo, W. Blattner, and E. H. Chang. "Germ-line Transmission of a Mutated p53 Gene in a Cancer-Prone Family with Li-Fraumeni Syndrome." Nature 348 (1990): 747–9. Paper 2 Baker, S. J., E. R. Fearon, J. M. Nigro, S. R. Hamilton, A. C. Preisinger, J. M. Jessup, P. vanTuinen, D. H. Ledbetter, D. F. Barker, Y. Nakamura, R. White, and B. Vogelstein. "Chromosome 17 Deletions And p53 Gene Mutations in Colorectal Carcinomas." Science 244 (1989): 217–21.
5	p53 and cancer mouse models See the Lecture Summary	Paper 1 Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery, J. S. Butel, and A. Bradley. "Mice Deficient for p53 are Developmentally Normal but Susceptible to Spontaneous Tumours." Nature 356 (1992): 215–21. Paper 2 Jacks, T., L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi, R. T. Bronson, and R. A. Weinberg. "Tumor Spectrum analysis in p53-Mutant Mice." Curr Biol 4 (1994): 1-7.
6	p53 and programmed cell death (apoptosis) See the Lecture Summary	Paper 1 Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren. "Wild-Type p53 Induces Apoptosis of Myeloid Leukaemic Cells that is Inhibited by Interleukin-6." Nature 352 (1991): 345–7. Paper 2 Shaw, P., R. Bovey, S. Tardy, R. Sahli, B. Sordat, and J. Costa. "Induction of Apoptosis by Wild-Type p53 in a Human Colon Tumor-Derived Cell Line." Proc Natl Acad Sci USA 89 (1992): 4495–9.
7	p53 and cell cycle regulation See the Lecture Summary	Paper 1 Michalovitz, D., O. Halevy, and M. Oren. "Conditional Inhibition of Transformation and of Cell Proliferation by a Temperature-Sensitive Mutant of p53." Cell 62 (1990): 671–80. Paper 2 el-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. "WAF1, a Potential Mediator of p53 Tumor Suppression." Cell 75 (1993): 817–25.
8	p53, DNA damage and genome integrity See the Lecture Summary	Paper 1 Livingstone, L. R., A. White, J. Sprouse, E. Livanos, T. Jacks, and T. D. Tlsty. "Altered Cell Cycle Arrest and Gene Amplification Potential Accompany Loss of Wildtype p53." Cell 70 (1992): 923–35. Paper 2 Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein, and R. W. Craig. "Participation of p53 Protein in the Cellular Response to DNA Damage." Cancer Res 51 (1991): 6304–11.
9	Field Trip See the Lecture Summary	[No Readings]
10	p53 and Mdm2 See the Lecture Summary	Paper 1 Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine. "The Mdm-2 Oncogene Product Forms a Complex with the p53 Protein and Inhibits p53-Mediated Transactivation." Cell 69 (1992): 1237–45. Paper 2 Wu, X., J. H. Bayle, D. Olson, and A. J. Levine. "The p53-Mdm-2 Autoregulatory Feedback Loop." Genes Dev 7 (1993): 1126–32.
11	p53 and microRNA See the Lecture Summary	Paper 1 He, L., X. He, L. P. Lim, E. de Stanchina, Z. Xuan, Y. Liang, W. Zender, J. Magnus, D. Ridzon, A. L. Jackson, P. S. Linsley, C. Chen, S. W. Lowe, M. A. Cleary, and G. J. Hannon. "A microRNA Component of the p53 Tumour Suppressor Network." Nature 447 (2007): 1130–34. Paper 2 Chang, T. C., E. A. Wentzel, O. A. Kent, K. Ramachandran, M. Mullendore, K. H. Lee, G. Feldmann, M. Yamakuchi, M. Ferlito, C. J. Lowenstein, D. E. Arking, M. A. Beer, A. Maitra, and J. T. Mendell. "Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis." Mol Cell 26 (2007): 745–52.
12	p53 restoration therapy See the Lecture Summary	Paper 1 Bykov, V. J., N. Issaeva, A. Shilov, M. Hultcrantz, E. Pugacheva, P. Chumakov, J. Bergman, K. G. Wiman, and G. Selivanova. "Restoration of the Tumor Suppressor Function to Mutant p53 by a Low-Molecular-Weight Compound." Nat Med 8 (2002): 282-8. Paper 2 Martins, C. P., L. Brown-Swigart, and G. I. Evan. "Modeling the Therapeutic Efficacy of p53 Restoration in Tumors." Cell 127 (2006): 1323-34.
13	Final class See the Lecture Summary	[No readings]