1 |
Introduction |
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2 |
The Discovery of RNA Interference |
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3 |
The Basic Mechanism of RNAi |
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4 |
Physiological Relevance of the RNAi Pathway |
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5 |
Short-interfering RNAs (siRNAs) and their Delivery to Cells |
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6 |
Stable Expression of siRNA: Short Hairpins and Expression Vectors |
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7 |
Generation of Transgenic Animals for in vivo Silencing |
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8 |
Field Trip to Mouse-transgenesis Facility |
Assignment 1 due |
9 |
Discussion of First Written Assignment |
Choose journal article papers for second assignment |
10 |
Design of Potent siRNA Sequences |
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11 |
Large-scale Genetic Analyses Using RNAi |
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12 |
Student Oral Presentations of their Chosen Papers |
Assignment 2 due |
13 |
Using RNAi in the Prevention of Disease |
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14 |
Course Summary and Discussion on the Future of RNAi |
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