| 1 |
Background of Protein Misfolding and Disease |
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| 2 |
Origins of the Protein-only Hypothesis of Prions |
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| 3 |
Controversial Evidence against the Virus-hypothesis of Prion |
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| 4 |
Pathology of the Transmissible Spongiform Encephalopathies |
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| 5 |
Structure of the Prion Protein |
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| 6 |
The Prion Species Barrier |
Assignment 2 due |
| 7 |
Detection of Prion Diseases in Humans and Animals |
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| 8 |
Alzheimer's Disease |
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| 9 |
Transmission Electron Microscopy: Field trip to TEM facility |
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| 10 |
Oligomeric Ring Structures in Alzheimer's and Parkinson's Disease |
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| 11 |
Parkinson's Disease and α-synuclein |
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| 12 |
Polyglutamine repeats in Kennedy's and Huntington's Diseases |
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| 13 |
Senile Systematic Amyloidosis and Inflammation |
Assignment 3 proposal due |
