Cell Cycle & Its Regulation

 

Cell Cycle–Overview

Overview of the phases of the cell cycle: M (mitosis), G1 (gap1), S (synthesis), and G2 (gap2). Mitosis is further divided into subphases-interphase, prophase, metaphase, anaphase, and telophase.

Course Material Related to This Topic:

  • Watch video clip from Lecture 19 (0:59 - 13:07)

Upward arrow. Back to Top

Cell Growth and Division

The study of cell cycle phases using drugs that reversibly block proteins necessary in different phases. Drugs can create a synchronized population of cells that are in the same phase of the cell cycle.

Course Material Related to This Topic:

  • Watch video clip from Lecture 19 (13:07 - 32:40)

Upward arrow. Back to Top

Cell Cycle–Regulation I and II

Growth factor proteins released from neighboring cells bind to receptors on a cell to induce cell division. The G1/S checkpoint in the cell cycle restricts cell division unless the cell senses external growth factors.

Course Material Related to This Topic:

  • Watch video clip from Lecture 19 (38:03 - 48:31)
  • Watch video clip from Lecture 20 (8:17 - 10:09)

Upward arrow. Back to Top

Cancer Cells, Mutagens, and Carcinogens

A single abnormal progenitor cell can form a tumor. Compare growth pattern of normal cells in monolayers and cancerous cells in multiple layers.

Course Material Related to This Topic:

  • Watch video clip from Lecture 20 (38:12 - 44:00)

Upward arrow. Back to Top

Cancer and Mutations

Mutations in the genes that regulate cell cycle and division can cause cancer. Mutations in somatic cells arise spontaneously or from exposure to chemical mutagens.

Course Material Related to This Topic:

  • Watch video clip from Lecture 20 (44:00 - 49:17)

Upward arrow. Back to Top

Mutagens and Carcinogens

There is a correlation between mutagens that induce mutations and carcinogens that induce tumor formation.

Course Material Related to This Topic:

  • Watch video clip from Lecture 21 (1:39 - 5:46)

Upward arrow. Back to Top

Cell Characteristics

Cell division, metabolism, growth, and reproduction. Movie of division of baker's yeast.

Course Material Related to This Topic:

  • Watch video clip from Lecture 4 (38:20 - 41:47)

Upward arrow. Back to Top

Cancer

A brief description of the failure of cell cycle regulation, leading to cancer.

Course Material Related to This Topic:

  • Watch video clip from Lecture 11 (24:51 - 28:51)

Upward arrow. Back to Top

Cell Regulatory Decisions

Reversible (e.g. metabolic) and irreversible (e.g. developmental) regulations within the cell.

Course Material Related to This Topic:

  • Watch video clip from Lecture 13 (33:17 - 36:56)

Upward arrow. Back to Top

Cell Cycle and Regulation

Phases of the cell cycle and multiple check points. Use yeast cell cycle temperature sensitive mutants to identify genes involved in cell cycle regulation.

Course Material Related to This Topic:

  • Watch video clip from Lecture 22 (29:55 - 37:38)

Upward arrow. Back to Top

Checkpoints

A discussion of checkpoints in the phases of the cell cycle.

Course Material Related to This Topic:

Upward arrow. Back to Top

Cell Death

Method, purpose, and scientific history of programmed cell death, from initial signal to phagocytosis by surrounding cells.

Course Material Related to This Topic:

Upward arrow. Back to Top