Viral Structure & Replication


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Video Clips

Video RealVideo®
6:05 minutes (21:23 - 27:28)

Life cycle of viruses with different types of genomes. Some viruses containing RNA genomes use reverse transcriptase to make DNA from RNA. Example: HIV.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: DNA replication and transcription
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Video RealVideo®
13:30 minutes (2:20 - 15:50)

Life cycle and infection of the polio virus. Jenner and his discovery of vaccine for polio. Vaccines can be made from heat attenuated or formaldehyde treated polio viruses.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Viral life cycle
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Video RealVideo®
34:25 minutes (15:38 - 50:03)

History of AIDS, discovery of HIV, life cycle, infection, and inhibitors of HIV.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Video RealVideo®
9:14 minutes (5:44 - 14:58)

Structure and mechanism of replication of RNA viruses that synthesize RNA from RNA template. Example: Tobacco mosaic virus. Structure and integration of retroviruses that use reverse transcriptase to make DNA from RNA template. Example: HIV.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Video RealVideo®
6:28 minutes (17:54 - 24:22)

Structure, infection, and life cycle of bacterial virus. Plaque formation upon infection.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Lecture Notes

Document PDF
All pages

Structure, life cycle, and examples of all types of viruses classified by their genomes. Clear and detailed summary of virology.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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HIV

Document PDF
All pages

Comprehensive review of the structure, life cycle, and infection of the human immunodeficiency virus.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Use with AIDS sections
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Practice Problems

Document PDF#
Problem 1

Immune response to viral infections and how viruses try to evade the system.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF#
Problem 4

Various viral genomes and incorporation into the host genome.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Restriction enzymes and gel electrophoresis
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Document PDF
Problem 4I (page 4)

Order of events occurring through the life cycle of HIV.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Document PDF
Problem 4III-4V (page 5)

Potential drug targets in the HIV life cycle.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Document PDF
Problem 1B (page 3)

HIV life cycle, reverse transcriptase, integrase, and drugs that prevent HIV reproduction.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Exam Questions

Document PDF#
Problem 5 (page 8)

Structure and life cycle of viruses. Viral infections and potential to cause AIDS and cancer.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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