Meiosis & Gametogenesis


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Video Clips

Video RealVideo®
7:35 minutes (41:50 - 49:25)

The discovery of chromosomes and brief overview of meiosis in the context of Mendel's work. Chromosome theory of inheritance-traits are carried on chromosomes that segregate when gametes form.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Mendel's experiments
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Video RealVideo®
4:21 minutes (2:05 - 6:26)

Brief overview of mitosis and meiosis and the segregation of chromosomes in the context of Mendel's theory.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Follows from previous lecture
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Video RealVideo®
4:13 minutes (10:40 - 14:53)

Two traits that are on the same chromosome may not segregate independently. Genetic linkage reconciles Mendel's theory and the Chromosomal Theory of Inheritance.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Video RealVideo®
9:45 minutes (16:48 - 26:33)

Explanation of steps and characteristics of meiosis. Definition: Meiosis I and II, chiasma

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: Chromosomes and mitosis
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Video RealVideo®
3:22 minutes (26:33 - 29:55)

Fertilization and the combination of chromosomes from the egg and sperm. Chromosomes as the carriers of genetic particles.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: Chromosomes and meiosis
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Video RealVideo®
2:34 minutes (44:53 - 47:27)

Inaccurate segregation of chromosomes. Trisomy and monosomy as result of defects in meiosis.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: Meiosis
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Audio Clips

Audio RealAudio®
10:55 minutes (5:14 - 16:09)

Detailed description of steps of meiosis I and meiosis II and comparison to mitosis. Should use in conjunction with textbook diagrams.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Audio RealAudio®
5:29 minutes (16:09 - 21:38)

Explanation of homologous recombination that occurs during the prophase of meiosis I. Generation of new chromatids and chromosomes during recombination give rise to diversity.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: Meiosis
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Audio RealAudio®
3:21 minutes (21:38 - 24:59)

How errors in meiosis occur, and how these errors are manifested in the final organism.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: Meiosis
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Audio RealAudio®
7:31 minutes (16:04 - 23:35)

Lineages for the sperm and egg. Cell divisions and differentiations during the formation process.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Hormonal Control of Gametogenesis (7.013, Spring 2005)

Audio RealAudio®
6:33 minutes (29:05 - 35:38)

Hormones as long-range inducers for gametogenesis. Produced in the brain, travel through the blood stream to the ovaries and testes. Balance of various stimulatory and inhibitory hormones and feedback loop induce gametogenesis.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Practice Problems

Document PDF#
Problem 3 (page 4)

Comparison between chromosomal segregation during mitosis, meiosis I and meiosis II and DNA recombination.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF#
Problem 2 (page 2)

Transcription and translation of a given gene and DNA mutations that affect the protein product.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF
Problem 4 (page 5)

Inheritance of traits based on segregation of chromosomes.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Mitosis vs. Meiosis (7.013, Spring 2005)

Document PDF
All problems (all pages)

Table comparing cell division through mitosis and meiosis-process and cellular components involved.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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