Eukaryotic Chromosomes


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Video Clips

Video RealVideo®
4:14 minutes (6:26 - 10:40)

Independent assortment of traits and chromosomes demonstrated by dihybrid crosses with two traits.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Mendel's Law of Segregation and Chromosomes
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Video RealVideo®
14:14 minutes (14:53 - 29:07)

Morgan's experiments with fruit flies showed linkage between two genes/traits. Dihybrid crosses with two traits show genetic recombination and genetic distances.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Mendel's Law of Segregation and Chromosomes
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Video RealVideo®
13:39 minutes (29:07 - 42:46)

Sturtevant's work with multiple traits mapped out genes on chromosomes based on recombination frequencies. Genetic maps allowed biologists to predict frequency of double recombination.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Genetic linkage, distance, and recombination
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Video RealVideo®
8:29 minutes (42:46 - 51:15)

X and Y chromosomes determine gender. In fruit flies, certain physical traits such as eye color lie on the X chromosome and are linked to the sex of the fly.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Genetic linkage, distance, and recombination
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Video RealVideo®
12:26 minutes (8:57 - 21:23)

Eukaryotes and prokaryotes vary in DNA replication due to differences in chromosome structure and genome sizes.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: DNA replication
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Video RealVideo®
7:35 minutes (41:50 - 49:25)

The discovery of chromosomes and brief overview of meiosis in the context of Mendel's work. Chromosome theory of inheritance-traits are carried on chromosomes that segregate when gametes form.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Mendel's experiments
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Video RealVideo®
4:21 minutes (2:05 - 6:26)

Brief overview of mitosis and meiosis and the segregation of chromosomes in the context of Mendel's theory.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Follows from previous lecture
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Video RealVideo®
9:05 minutes (7:43 - 16:48)

Characteristics of chromosomes. Drawing of mitosis and the changes and segregation of chromosomes. Definition: Mitosis, chromosome, chromatid, and centrosome. Great video of mitosis.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Video RealVideo®
8:32 minutes (36:48 - 45:20)

Autosomes versus sex chromosomes. Morgan's experiment which discovered sex-linkage. Carriers and inheritance patterns.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: Meiosis and genetic linkage
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Audio Clip

Genes and Chromosomes (7.013, Spring 2006)

Audio RealAudio®
4:34 minutes (0:40 - 5:14)

Details about genes, chromosomes, and the human genome.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Lecture Notes

Document PDF
Big Idea 2

Clarification of genes, alleles, traits, genotype, phenotype, and dominance.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Practice Problems

Document PDF#
Problem 2 (page 2)

Recombination between two linked genes used to construct genetic maps.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF#
Problem 3 (page 4)

Comparison between chromosomal segregation during mitosis, meiosis I and meiosis II and DNA recombination.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF
Problem 1 (page 1)

Use family pedigree to predict the mode of inheritance. Predict gene arrangement on the chromosomes based on linkage.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Document PDF
Problem 2 (page 2)

Characteristics of linked genes and calculation of recombination frequencies.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Document PDF
All problems (All pages)

Table comparing cell division through mitosis and meiosis-process and cellular components involved.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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Document PDF
Problem A (page 1)

Conceptual questions on the Chromosomal Theory of Inheritance, sexual reproduction, and chromosomal recombination.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Document PDF
Problem B (page 1)

Two examples of human pedigrees used to predict the mode of inheritance. Recombination is taken into consideration when calculating probability of inheritance.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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