Coupled Reactions


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Video Clips

Video RealVideo®
22:34 minutes (18:07 - 40:41)

Using steps of glycolysis to demonstrate energetics of a multistep pathway. The process involves consuming and generating ATP, pyruvate and NADH. Krebs cycle uses pyruvate from glycolysis and oxygen to make NADH, FADH, and ATP.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Builds on the previous section
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Video RealVideo®
3:16 minutes (40:41 - 43:57)

Anaerobic and aerobic conditions produce different amounts of energy in terms of ATP.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Follows from previous section on glycolysis and krebs cycle
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Video RealVideo®
9:26 minutes (33:09 - 42:35)

Storage of energy in chemical bonds with ATP as the energy currency. Example: Coupling glutamate to glutamine reaction and C6H12O6 to lactate reaction.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Video RealVideo®
5:51 minutes (14:01 - 19:52)

Definition of oxidation and reduction. Coupled transfer of electrons or hydrogen atoms. Example: NADH to NAD+.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Lecture Notes

Document PDF#
Page 3 to page 4

Use glycolysis as an illustration of chemical reactions. Emphasis on the production of ATP as an energy currency.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Document PDF
Page 1 to page 2

Classification of organisms based on carbon source, energy source, and electron donor. Name, definition and examples from each class.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Practice Problems

Document PDF
Problem A (page 1)

The importance of biochemical reactions in life.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Document PDF
Problem D (page 4)

Coupled reactions used to run thermodynamically unfavorable reactions. ATP used as an energy storage intermediate.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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