Cell Cycle & Its Regulation


Video Clips

Video RealVideo®
12:08 minutes (0:59 - 13:07)

Overview of the phases of the cell cycle: M (mitosis), G1 (gap1), S (synthesis), and G2 (gap2). Mitosis is further divided into subphases-interphase, prophase, metaphase, anaphase, and telophase.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Video RealVideo®
19:33 minutes (13:07 - 32:40)

The study of cell cycle phases using drugs that reversibly block proteins necessary in different phases. Drugs can create a synchronized population of cells that are in the same phase of the cell cycle.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Cell cycle
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Video RealVideo®
10:28 minutes (38:03 - 48:31)

Growth factor proteins released from neighboring cells bind to receptors on a cell to induce cell division. The G1/S checkpoint in the cell cycle restricts cell division unless the cell senses external growth factors.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Video RealVideo®
1:52 minutes (8:17 - 10:09)

Growth factor proteins released from neighboring cells bind to receptors on a cell to induce cell division. The G1/S checkpoint in the cell cycle restricts cell division unless the cell senses external growth factors.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: None
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Video RealVideo®
5:48 minutes (38:12 - 44:00)

A single abnormal progenitor cell can form a tumor. Compare growth pattern of normal cells in monolayers and cancerous cells in multiple layers.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Cell cycle
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Video RealVideo®
5:17 minutes (44:00 - 49:17)

Mutations in the genes that regulate cell cycle and division can cause cancer. Mutations in somatic cells arise spontaneously or from exposure to chemical mutagens.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Cell cycle, mutations
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Video RealVideo®
4:07 minutes (1:39 - 5:46)

There is a correlation between mutagens that induce mutations and carcinogens that induce tumor formation.

Instructors: Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Prior Knowledge: Mutations
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Video RealVideo®
3:27 minutes (38:20 - 41:47)

Cell division, metabolism, growth, and reproduction. Movie of division of baker's yeast.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Video RealVideo®
4:00 minutes (24:51 - 28:51)

A brief description of the failure of cell cycle regulation, leading to cancer.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: DNA
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Video RealVideo®
3:39 minutes (33:17 - 36:56)

Reversible (e.g. metabolic) and irreversible (e.g. developmental) regulations within the cell.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Video RealVideo®
7:43 minutes (29:55 - 37:38)

Phases of the cell cycle and multiple check points. Use yeast cell cycle temperature sensitive mutants to identify genes involved in cell cycle regulation.

Instructors: Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Prior Knowledge: None
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Audio Clips

Audio RealVideo®
3:43 minutes (36:25 - 40:08)

A discussion of checkpoints in the phases of the cell cycle.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: The cell cycle
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Audio RealVideo®
9:16 minutes (40:08 - 49:24)

Method, purpose, and scientific history of programmed cell death, from initial signal to phagocytosis by surrounding cells.

Instructors: Prof. Tyler Jacks, Prof. Hazel Sive
Prior Knowledge: None
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