Overview of the phases of the cell cycle: M (mitosis), G1 (gap1), S (synthesis), and G2 (gap2). Mitosis is further divided into subphases-interphase, prophase, metaphase, anaphase, and telophase.
The study of cell cycle phases using drugs that reversibly block proteins necessary in different phases. Drugs can create a synchronized population of cells that are in the same phase of the cell cycle.
Growth factor proteins released from neighboring cells bind to receptors on a cell to induce cell division. The G1/S checkpoint in the cell cycle restricts cell division unless the cell senses external growth factors.
Growth factor proteins released from neighboring cells bind to receptors on a cell to induce cell division. The G1/S checkpoint in the cell cycle restricts cell division unless the cell senses external growth factors.
A single abnormal progenitor cell can form a tumor. Compare growth pattern of normal cells in monolayers and cancerous cells in multiple layers.
Mutations in the genes that regulate cell cycle and division can cause cancer. Mutations in somatic cells arise spontaneously or from exposure to chemical mutagens.
There is a correlation between mutagens that induce mutations and carcinogens that induce tumor formation.
Cell division, metabolism, growth, and reproduction. Movie of division of baker's yeast.
A brief description of the failure of cell cycle regulation, leading to cancer.
Reversible (e.g. metabolic) and irreversible (e.g. developmental) regulations within the cell.
Phases of the cell cycle and multiple check points. Use yeast cell cycle temperature sensitive mutants to identify genes involved in cell cycle regulation.
A discussion of checkpoints in the phases of the cell cycle.
Method, purpose, and scientific history of programmed cell death, from initial signal to phagocytosis by surrounding cells.